Which cells of the human body have the least regenerative power?

In the human body, brain cells possess the least regenerative capacity compared to other cell types. Unlike many tissues capable of repair and regeneration, such as skin or liver cells, neurons in the brain have limited ability to regenerate after injury or damage. This is primarily due to the unique and intricate structure of neurons, their complex interconnections, and the limited presence of neural stem cells in certain regions of the brain.
While some degree of plasticity and repair mechanisms exist, the regeneration of lost or damaged neurons is notably limited in the central nervous system. Consequently, injuries or degenerative conditions affecting the brain can often result in permanent functional deficits. Understanding the mechanisms underlying neuronal regeneration and harnessing potential therapeutic strategies remain significant challenges in neuroscience, with implications for the treatment of neurological disorders and injuries.