The hormone insulin, secreted by the pancreas, controls the level of glucose in the blood. When insulin production is insufficient, glucose is not converted into glycogen for storage, leading to high blood sugar levels. This condition is called diabetes mellitus. It causes fatigue, frequent urination, and increased thirst. Hence, the correct answer is insulin from the pancreas, as its lack is responsible for abnormally high glucose levels in the patient’s bloodstream. The correct option is (D).