Besides better aeration and mixing properties, what other advantages do stirred tank bioreactors have over shake flasks?

The shake flask method is used for a small-scale production of biotechnological products in a laboratory. On the other hand, stirred tank bioreactors are used for a large-scale production of biotechnology products.
Stirred tank bioreactors have several advantages over shake flasks. Some of them are
1. Small volumes of culture can be taken out from the reactor for sampling or testing.
2. It has a foam breaker for regulating the foam.
3. It has a control system that regulates the temperature and pH.

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