Polar protic solvents, such as water, alcohol, and acetic acid, are commonly used in SN₁ reactions.

Ambident nucleophiles, like cyanides and nitrites, have two nucleophilic centers. Cyanide can act through the carbon atom (⁻C≡N) or nitrogen atom (⁻:C=N⁻), forming alkyl cyanides or isocyanides. Similarly, nitrite ion can link through oxygen (⁻O—:N=O) to form alkyl nitrites or ...

Nucleophilic substitution reactions are valuable for alkyl halides with sp³ hybridized carbon. These reactions are initiated by nucleophiles, attacking the partially positively charged carbon atom in the haloalkane, resulting in substitution with the departing halide ion.

Nucleophiles are electron-rich species that attack the electron-deficient part of a substrate molecule, leading to nucleophilic substitution reactions. In these reactions, a nucleophile reacts with a haloalkane, replacing the existing nucleophile, and the departing halogen forms a halide ion.

Haloalkanes tend to dissolve in organic solvents because the new intermolecular attractions between haloalkanes and solvent molecules have similar strength to the attractions being broken in separate haloalkane and solvent molecules, leading to higher solubility in organic solvents.