Jaundice primarily affects the (b) Liver. It occurs due to an accumulation of bilirubin, a yellow pigment, in the bloodstream. The liver normally processes bilirubin, but when it’s unable to do so effectively, often due to liver disease or obstruction of the bile ducts, jaundice develops. While the liver is the primary organ affected by jaundice, other organs like the spleen (c) and gallbladder (d) can be impacted indirectly, as jaundice may result from conditions affecting these organs, but the liver’s dysfunction is typically the underlying cause of jaundice. The heart (a) is not directly involved in jaundice.