Which cell organelle plays a crucial role in detoxifying many poisons and drugs in a cell?

(C) Smooth endoplasmic reticulum
Smooth endoplasmic reticulum in the liver cells of vertebrates helps in detoxification. It metabolizes various toxic or toxic substances such as drugs, aspirin, pesticides (DDT), petroleum products and pollutants. These toxic substances enter the body of animals through food, air or water.