Ergot is obtained from Claviceps. This genus comprises fungi that parasitize grasses and cereals, notably rye. Certain species of Claviceps produce alkaloids, including ergotamine and ergometrine, which can cause ergotism, a serious condition affecting humans and animals. Historically, ergotism outbreaks, known as “St. Anthony’s fire,” were linked to consumption of contaminated grain. Ergot alkaloids have also been used medicinally, notably in obstetrics to induce uterine contractions. However, due to their potent vasoconstrictive properties, they can also be toxic. Claviceps sclerotia, known as ergots, contain these alkaloids and have been associated with hallucinogenic effects and potential therapeutic uses. Despite their toxic potential, ergots have historically played a role in medicine and folklore, contributing to our understanding of fungal biology and the complex interactions between fungi and their hosts in agricultural and medical contexts.