Amines and alcohols with nitrogen and oxygen having electronegativities of 3.0 and 3.5, respectively, exhibit different solubility patterns in water, with alcohols generally being more soluble.
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Gabriel synthesis involves treating phthalimide with ethanolic potassium hydroxide, followed by heating with alkyl halide and alkaline hydrolysis to produce primary amines. However, this method cannot be used for aromatic primary amines as aryl halides do not undergo nucleophilic substitution ...
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