Cautionary advice regarding handling alkalis includes wearing protective gear such as gloves and goggles to prevent skin and eye contact. Alkalis, particularly strong ones like sodium hydroxide (NaOH), can cause severe burns and eye damage. Avoid inhaling alkali fumes, as they may be harmful to the respiratory system. When diluting alkalis, add the substance to water slowly to control heat release, as the dissolution of strong alkalis is exothermic. Promptly neutralize and wash off any spilled alkali with copious amounts of water. Adequate ventilation is essential when working with alkalis to minimize exposure to vapors.